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  "ediid": "76F046F18CCA46FBE05324570681CB301977",
  "title": "Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data measured between 3.6 degrees C and 25.4 degrees C for the Fab Fragment of NISTmAb",
  "contactPoint": {
    "name": "Jeffrey Hudgens",
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    "fn": "Jeffrey Hudgens"
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  "description": [
    "The spreadsheet file reported herein provides centroid data, descriptive of deuterium uptake, for the Fab Fragment of NISTmAb (PDB: 5K8A) reference material, as measured by the bottom-up hydrogen-deuterium exchange mass spectrometry (HDX-MS) method. The protein sample was incubated in deuterium-rich solutions under uniform pH and salt concentrations between 3.6 degrees C and 25.4 degrees C for seven intervals ranging (0 to 14,400) s plus a control sample that simulates a Fab Fragment immersed for infinite time in D2O. The deuterium content of peptic peptide fragments were measured by mass spectrometry. These data were reported by fifteen laboratories, which conducted the measurements using orbitrap and Q-TOF mass spectrometers. The cohort reported about 78,900 centroids for 430 proteolytic peptide sequences of the heavy and light chains of NISTmAb, providing nearly 100 % coverage. The instrumentation and physical and chemical conditions under which these data were acquired are documented."
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    "reproducibility"
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    "Metrology:Amount of substance",
    "Chemistry:Molecular characterization",
    "Chemistry:Analytical chemistry",
    "Bioscience:Cell biology",
    "Bioscience:Proteomics",
    "Bioscience:Biomaterials",
    "Chemistry:Chemical thermodynamics and chemical properties",
    "Manufacturing:Biomanufacturing",
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      "title": "HDX-MS centroid data for NISTmAb"
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    {
      "fn": "Jeffrey W. Hudgens",
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      "affiliation": [
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            "org:Organization"
          ],
          "title": "National Institute of Standards and Technology, Bioprocess Measurement Group, Biomolecular Measurements Division",
          "@id": "grid.94225.38"
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        {
          "@type": [
            "org:Organization"
          ],
          "title": "Institute for Bioscience and Biotechnology Research"
        }
      ]
    },
    {
      "fn": "Elyssia S. Gallagher",
      "givenName": "Elyssia",
      "middleName": "S.",
      "familyName": "Gallagher",
      "orcid": "0000-0002-5411-7285",
      "affiliation": [
        {
          "@type": [
            "org:Organization"
          ],
          "title": "National Institute of Standards and Technology, Bioprocess Measurement Group, Biomolecular Measurements Division",
          "@id": "grid.94225.38"
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        {
          "@type": [
            "org:Organization"
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          "title": "Institute for Bioscience and Biotechnology Research"
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    },
    {
      "fn": "Ioannis Karageorgos",
      "givenName": "Ioannis",
      "familyName": "Karageorgos",
      "affiliation": [
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          "title": "National Institute of Standards and Technology, Bioprocess Measurement Group, Biomolecular Measurements Division",
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        {
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          "title": "Institute for Bioscience and Biotechnology Research"
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      ]
    },
    {
      "fn": "Kyle W. Anderson",
      "givenName": "Kyle",
      "middleName": "W.",
      "familyName": "Anderson",
      "orcid": "0000-0002-2808-3026",
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          "title": "National Institute of Standards and Technology, Bioprocess Measurement Group, Biomolecular Measurements Division",
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          "title": "Institute for Bioscience and Biotechnology Research"
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    },
    {
      "fn": "Richard Y.-C. Huang",
      "givenName": "Richard",
      "middleName": "Y.-C.",
      "familyName": "Huang",
      "orcid": "0000-0002-7172-110X",
      "affiliation": [
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          "title": "Bristol-Myers Squibb Company",
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    {
      "fn": "Guodong Chen",
      "givenName": "Guodong",
      "familyName": "Chen",
      "orcid": "0000-0002-5531-407X",
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          "title": "Bristol-Myers Squibb Company",
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    {
      "fn": "George M. Bou-Assaf",
      "givenName": "George",
      "middleName": "M.",
      "familyName": "Bou-Assaf",
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          "title": "Biogen Inc.",
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    {
      "fn": "Alfonso Espada",
      "givenName": "Alfonso",
      "familyName": "Espada",
      "orcid": "0000-0002-8301-1201",
      "affiliation": [
        {
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          "title": "Centro de Investigaci\u00f3n Lilly S.A.",
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    {
      "fn": "Michael J. Chalmers",
      "givenName": "Michael",
      "middleName": "J.",
      "familyName": "Chalmers",
      "affiliation": [
        {
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          ],
          "title": "Lilly Research Laboratories, Eli Lilly and Company",
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    {
      "fn": "Eduardo Harguindey",
      "givenName": "Eduardo",
      "familyName": "Harguindey",
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          "title": "Genentech, Inc."
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    {
      "fn": "Benjamin T. Walters",
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      "middleName": "T.",
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    {
      "fn": "Jennifer Zhang",
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      "fn": "John Venable",
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          "title": "Genomics Institute of the Novartis Research Foundation",
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    {
      "fn": "Caitlin Steckler",
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          "title": "Genomics Institute of the Novartis Research Foundation",
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          "title": "Joint Center for Structural Genomics",
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    {
      "fn": "Inhee Park",
      "givenName": "Inhee",
      "familyName": "Park",
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          "title": "Genomics Institute of the Novartis Research Foundation",
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    {
      "fn": "Ansgar Brock",
      "givenName": "Ansgar",
      "familyName": "Brock",
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          ],
          "title": "Genomics Institute of the Novartis Research Foundation",
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      ]
    },
    {
      "fn": "Xiaojun Lu",
      "givenName": "Xiaojun",
      "familyName": "Lu",
      "affiliation": [
        {
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          ],
          "title": "MedImmune LLC"
        }
      ]
    },
    {
      "fn": "Ratnesh Pandey",
      "givenName": "Ratnesh",
      "familyName": "Pandey",
      "orcid": "0000-0002-0072-6480",
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        {
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          ],
          "title": "MedImmune LLC"
        }
      ]
    },
    {
      "fn": "Arun Chandramohan",
      "givenName": "Arun",
      "familyName": "Chandramohan",
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          ],
          "title": "National University of Singapore",
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    {
      "fn": "Ganesh Srinivasan Anand",
      "givenName": "Anand",
      "familyName": "Srinivasan",
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      "fn": "Sasidhar N. Nirudodhi",
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          "title": "University of Copenhagen",
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    },
    {
      "fn": "Ulrike Leurs",
      "givenName": "Ulrike",
      "familyName": "Leurs",
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          "title": "University of Pennsylvania, Department of Pathology & Laboratory Medicine, Perelman School of Medicine",
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    {
      "fn": "David D. Weis",
      "givenName": "David",
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    {
      "fn": "Tyler S. Hageman",
      "givenName": "Tyler",
      "middleName": "S.",
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    },
    {
      "fn": "Daniel Deredge",
      "givenName": "Daniel",
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          "title": "University of Maryland, Baltimore, School of Pharmacy, Department of Pharmaceutical Sciences",
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    {
      "fn": "Patrick L. Wintrode",
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      "familyName": "Papanastasiou",
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          ],
          "title": "University of Pennsylvania, Department of Pathology & Laboratory Medicine, Perelman School of Medicine",
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    {
      "fn": "John D. Lambris",
      "givenName": "John",
      "middleName": "D.",
      "familyName": "Lambris",
      "orcid": "0000-0002-9370-5776",
      "affiliation": [
        {
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          "title": "University of Pennsylvania, Department of Pathology & Laboratory Medicine, Perelman School of Medicine",
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      ]
    },
    {
      "fn": "Sheng Li",
      "givenName": "Sheng",
      "familyName": "Li",
      "affiliation": [
        {
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            "org:Organization"
          ],
          "title": "University of California, San Diego, Department of Medicine",
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    {
      "fn": "Sarah Urata",
      "givenName": "Sarah",
      "familyName": "Urata",
      "affiliation": [
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          ],
          "title": "University of California, San Diego, Department of Medicine",
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