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  "title": "NMR Interlaboratory Study of NISTmAb",
  "contactPoint": {
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    "The NISTmAb Interlaboratory NMR Study is a joint effort between 25 organizations to evaluate the performance of two-dimensional (2D) heteronuclear NMR as used to characterize the high order structure (HOS) of proteins, with the aim of harmonizing 2D-NMR methods to support industrial use of NMR as applied to mAb therapeutics. This study features nearly equal representation between laboratories from academia, government, and industry, including 4 laboratories from regulatory agencies. In the study, each participating lab measured a series of NMR spectra on the NIST-Fab, which was derived by papain cleavage of the NISTmAb. A 20%-enriched 13C, uniformly enriched 15N NIST-Fab, produced from Pichia pastoris, served as the system suitability sample.",
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      "title": "Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics",
      "issued": "2018-12-22",
      "citation": "Brinson, R. G., Marino, J. P., Delaglio, F., Arbogast, L. W., Evans, R. M., Kearsley, A., Gingras, G., Ghasriani, H., Aubin, Y., Pierens, G. K., Jia, X., Mobli, M., Grant, H. G., Keizer, D. W., Schweimer, K., St\u00c3\u00a5hle, J., Widmalm, G., Zartler, E. R., Lawrence, C. W., \u00e2\u0080\u00a6 Wikstr\u00c3\u00b6m, M. (2018). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. MAbs, 11(1), 94\u00e2\u0080\u0093105. https://doi.org/10.1080/19420862.2018.1544454\n"
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      "title": "Best Practices in Utilization of 2D-NMR Spectral Data as the Input for Chemometric Analysis in Biopharmaceutical Applications",
      "issued": "2020-04-06",
      "citation": "Brinson, R. G., Arbogast, L. W., Marino, J. P., & Delaglio, F. (2020). Best Practices in Utilization of 2D-NMR Spectral Data as the Input for Chemometric Analysis in Biopharmaceutical Applications. Journal of Chemical Information and Modeling, 60(4), 2339\u00e2\u0080\u00932355. https://doi.org/10.1021/acs.jcim.0c00081\n"
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      "issued": "2020-04",
      "citation": "Sheen, D. A., Shen, V. K., Brinson, R. G., Arbogast, L. W., Marino, J. P., & Delaglio, F. (2020). Chemometric outlier classification of 2D-NMR spectra to enable higher order structure characterization of protein therapeutics. Chemometrics and Intelligent Laboratory Systems, 199, 103973. https://doi.org/10.1016/j.chemolab.2020.103973\n"
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