This data table contains the processed data for the LacI genotype-phenotype landscape, a quantitative measurement of the phenotype for approximately 60,000 variants of the E. coli LacI protein. The table includes, for example, the DNA barcode sequencing counts and the estimated fitness for each variant across 24 different chemical environments. It also includes the estimated dose-response curves for each variant under induction with IPTG.
Research Topics: Bioscience:Cell biology, Bioscience:Proteomics, Bioscience:Engineering/synthetic biology
Subject Keywords: allostery, E. coli, Lac repressor, fitness landscape, genotype-phenotype relationships, DNA barcode sequencing, engineering biology
These data are public.
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About This Dataset
Cite this dataset
David J. Ross (2020), LacI protein genotype-phenotype landscape data, National Institute of Standards and Technology, https://doi.org/10.18434/M32259 (Accessed 2023-12-07)
Machine-readable descriptions of this dataset are available in the following formats:
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